Here are my start code comparisons.

Here are my start code comparisons.

Slic3r that doesn’t work now, but worked on RAMPS/Marlin
G21
G91
G28 ; home all axes
G29
G1 Z5 F5000 ; lift nozzle

Cura that works with Redeem/Replicape
G21 ;metric values
G90 ;absolute positioning
M82 ;set extruder to absolute mode
M107 ;start with the fan off
G28 X0 Y0 ;move X/Y to min endstops
G28 Z0 ;move Z to min endstops
G1 Z15.0 F{travel_speed} ;move the platform down 15mm
G92 E0 ;zero the extruded length
G1 F200 E3 ;extrude 3mm of feed stock
G92 E0 ;zero the extruded length again
G1 F{travel_speed}
;Put printing message on LCD screen
M117 Printing…

Though I think the issue has something to do with that relative vs absolute extruder distances. I might try slic3r with no start gcode and put the cura start gcode in octoprint and see what happens.

Here’s my start G-Code:
; Default start code
; M80 ; Start ATX PSU if not already on.
G28 ; Home extruder
; G1 Z200 F4000 ; bring the head down before starting to move, disable when using G29
; G29 ; auto probe
M107 ; Turn off fan
G90 ; Absolute positioning
; M82 ; Extruder in absolute mode
{IF_BED}M190 S{BED}
; Activate all used extruder
{IF_EXT0}M104 T0 S{TEMP0}
G92 E0 ; Reset extruder position
M116 ; Wait for all temperatures set to be reached.
{IF_EXT0}M109 T0 S{TEMP0}

As you can see, I also have a G90 and G92… Maybe try to remove the G21? This is also ported over from my ramps…

I will give that a try tonight, thanks!

@Jon_Charnas You have been very helpful, a mix of your start code and my cura code placed in Octoprints start section worked to get slic3r going. I am not sure why placing said same code in slic3rs start code section caused the printer to move so slow.

I have no idea either - glad it worked!