S3D has huge issues crashing, the topics in the S3D forum all end unresolved, just users desperately trying to figure things out with no help from the software makers. this sucks having paid for it and now having to switch to a functioning free slicer…
I switched from S3D to Prusa’s edition of slic3r after they started doing some cool stuff with it. Still, I don’t think I’ve had too many issues with it crashing. Have you done a memtest? I recently had a bunch of random programs crashing left and right, turned out one of my ram sticks was faulty.
I haven’t had that many issues with it. It really messes up if the stl file has a lot of errors. But otherwise it still works well.
Got S3D working again, sort of, all my old settings and setup for single extrusion are gone 
I had to follow the recommended ‘save all profiles individually’ (because they are not in a folder one can copy), reset the software to default settings, create new printer profile (for the billionth time).
use a prebuilt printer profile for a delta with dual extrusion, picked the geeetech dual hotend, fix the settings related to two hotends i.e. the offset for the second tool.
the resulting process profile is IDENTICAL to what I created earlier, but now apparently works with the dual extrusion ‘wizard’ (more like evil witch than a wizard), and now doesn’t crash the software. it would not accept a perfectly modified profile for 2 extruders and single hotend without first starting with a prebuilts profile, and there is nowhere in the settings to indicate what is different. I wish I had more control over the configuration and settings and could easily copy the files from the OS file tree instead of clicking a menu scrolling to each profile for each filament and saving them individually. talk about tedious built in as a feature!
I’m in the same boat. The new version has never worked for me (crashes on startup). After swapping a few emails with support I have given up and moved to slicer (prusa edition)
@Matt_Shepherd annoyingly the fix for S3D v4 appears to be first save the profiles you want to save individually, using file>export FFF drop down menu to save each. Then reset to factory defaults. Apparently there is no simple folder of FFF profiles one can copy.
I uninstalled early versions as well, not sure if that is needed but I did it as the old versions seemed to not work after V4 was installed anyway. the software installs badly and reads old versions settings somehow, is what seems to be the problem.
This worked for me to stop the constant crashing. although it has crashed again once it seems usable at least now. I had maybe 30 profiles, but only needed to save 10 as some were for filament I will not buy again. all process created for different prints, printers, or model geometry, will be lost there does not seem to be a way to save those.
@AlohaMilton I couldn’t even export the profiles without it crashing 
Looking on the forum it appears I have the same issue as other users whos software crashes when a dialog/save/open window opens up.
I’ve uninstalled all versions of S3D, removed any S3D folders and tried a clean install, but the same thing happens and S3D supports only suggestion after this was to reinstall windows (Which I’m not going to do!)
I’m going to stick with Slicer/Prusa edition for a while, so far. so good. (The only thing I miss as the moement is manual supports, but I believe that is coming to Slicer soon)